A Copper-Catalyzed Formal [3 + 2]-Cycloaddition for the Synthesis of All Different Aryl-Substituted Furans and Thiophenes

J Org Chem. 2015 Aug 7;80(15):7555-63. doi: 10.1021/acs.joc.5b01139. Epub 2015 Jul 21.

Abstract

A highly efficient formal [3 + 2]-cycloaddition was established using a copper catalyst. The resulting dihydrofurans were subjected to oxidation followed by arylations to produce tetraarylfurans. In addition, the dihydrofuran can be converted to diaryldihydrothiophene by using Lawesson's reagent. This protocol will facilitate the synthesis of all different aryl-substituted furans and thiophenes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Copper / chemistry
  • Cycloaddition Reaction
  • Furans / chemical synthesis*
  • Furans / chemistry
  • Molecular Structure
  • Oxidation-Reduction
  • Thiophenes / chemical synthesis*
  • Thiophenes / chemistry

Substances

  • Furans
  • Thiophenes
  • Copper