Abstract
Human papillomavirus-associated oropharyngeal squamous cell carcinoma is now recognised as a subtype of head and neck cancer with distinct clinical, molecular and histological characteristics. The majority of these carcinomas are of non-keratinising squamous type but there is a growing number of histomorphologic variants of this disease. Here we describe the clinical, histomorphologic and immunophenotypic features of two cases of human papillomavirus-associated oropharyngeal squamous cell carcinoma demonstrating a clearly delineated biphasic differentiated and undifferentiated phenotype.
MeSH terms
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Biomarkers, Tumor / analysis
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Biopsy
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Carcinoma, Squamous Cell / chemistry
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Carcinoma, Squamous Cell / pathology*
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Carcinoma, Squamous Cell / therapy
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Carcinoma, Squamous Cell / virology*
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Cell Differentiation*
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Chemoradiotherapy
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DNA, Viral / genetics*
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Head and Neck Neoplasms / chemistry
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Head and Neck Neoplasms / pathology*
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Head and Neck Neoplasms / therapy
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Head and Neck Neoplasms / virology*
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Human Papillomavirus DNA Tests
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Humans
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Immunohistochemistry
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Male
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Middle Aged
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Oropharyngeal Neoplasms / chemistry
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Oropharyngeal Neoplasms / pathology*
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Oropharyngeal Neoplasms / therapy
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Oropharyngeal Neoplasms / virology*
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Papillomaviridae / genetics*
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Phenotype
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Predictive Value of Tests
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Squamous Cell Carcinoma of Head and Neck
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Treatment Outcome
Substances
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Biomarkers, Tumor
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DNA, Viral