Antibacterial Δ(1) -3-ketosteroids from the South China Sea gorgonian coral Subergorgia rubra

Chem Biodivers. 2015 Jul;12(7):1068-74. doi: 10.1002/cbdv.201400217.

Abstract

Three new Δ(1) -3-ketosteroids characterized with a 9-OH, subergosterones A-C (1-3), together with five known analogs 4-8, were obtained from the gorgonian coral Subergorgia rubra collected from the South China Sea. The structures of 1-3, including their absolute configurations, were determined by comprehensive spectroscopic methods and electronic circular dichroism (ECD) experiments. Compounds 2 and 3 exhibited inhibitory antibacterial activities against Bacillus cereus with MIC values of 1.56 μM.

Keywords: Antibacterial activity; Gorgonian; Subergorgia rubra; Subergosterones A - C; Δ1-3-Ketosteroid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Bacillus cereus / drug effects*
  • Dose-Response Relationship, Drug
  • Ketosteroids / chemistry
  • Ketosteroids / isolation & purification
  • Ketosteroids / pharmacology*
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • Ketosteroids