Abstract
A simple and practical method has been developed for the regioselective nitrosylation of imidazopyridines via C(sp(2))-H bond functionalization using tert-butyl nitrite under mild reaction conditions in a short time. A library of 3-nitrosoimidazopyridines with broad functionalities was synthesized in near quantitative yields. The present protocol is also applicable to imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]thiazole.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Imidazoles / chemical synthesis*
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Imidazoles / chemistry
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Molecular Structure
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Nitrites / chemistry*
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Nitroso Compounds / chemical synthesis*
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Nitroso Compounds / chemistry
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Pyridines / chemical synthesis*
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Pyridines / chemistry
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Stereoisomerism
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Thiazoles / chemical synthesis
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Thiazoles / chemistry
Substances
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Imidazoles
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Nitrites
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Nitroso Compounds
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Pyridines
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Thiazoles
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n-butyl nitrite