Objective: To report a case of endoscopic enucleation of a gastrointestinal stromal tumor of the ampulla of Vater.
Design: The tumor resection was performed by needle knife endoscopic submucosal dissection.
Results: The tumor was resected completely without serious complications and the patient recovered rapidly.
Conclusion: Endoscopic enucleation may be an alternative treatment for gastrointestinal stromal tumors of the ampulla of Vater for patients who fulfill certain requirements.
Keywords: Ampulla of vater; ESD; GIST.