Stereoselective α-indolylation of enals via an organocatalytic formal cross-coupling with indoles

Org Biomol Chem. 2015 Sep 7;13(33):8869-74. doi: 10.1039/c5ob01360g. Epub 2015 Jul 22.

Abstract

We report a novel organocatalytic one-pot cascade bromination-Michael-type Friedel-Crafts alkylation dearomatization-nucleophilic rearrangement aromatization cascade process for the direct α-indolylation of unfunctionalized enals from readily available indoles with good yields and high E selectivity. The simplicity and practicality of its high efficiency for formation of a new C(sp(2))-C(sp(2)) bond constitute the most attractive advantage of this reaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Hydrogen Bonding
  • Indoles / chemistry*
  • Models, Molecular
  • Molecular Conformation
  • Phenols / chemistry
  • Protons
  • Quantum Theory
  • Stereoisomerism
  • Thermodynamics

Substances

  • Indoles
  • Phenols
  • Protons