Abstract
HPLC-guided separation of twigs of Aglaia odorata led to the isolation of eight lignans, including two new ones, 3'-methoxy-N-demethylrocaglamide (1) and 4'-O-demethyl-deacetylaglaxiflorin A (2). Compound 1 showed excellent cytotoxicity against three human cancer cell lines, HeLa, SGC-7901 gastric cancer, and A-549 lung cancer with the values of 0.32, 0.12, and 0.25 μM, respectively.
Keywords:
3′-methoxy-N-demethylrocaglamide; 4′-O-demethyl-deacetylaglaxiflorin A; Aglaia odorata; Meliaceae; cytotoxicity.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aglaia / chemistry*
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification*
-
Antineoplastic Agents, Phytogenic / pharmacology
-
Drug Screening Assays, Antitumor
-
Drugs, Chinese Herbal / chemistry
-
Drugs, Chinese Herbal / isolation & purification*
-
Drugs, Chinese Herbal / pharmacology
-
HeLa Cells
-
Humans
-
Lignans / chemistry
-
Lignans / isolation & purification*
-
Lignans / pharmacology
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Plant Stems / chemistry
-
Stomach Neoplasms / drug therapy
Substances
-
3'-methoxy-N-demethylrocaglamide
-
4'-O-demethyl-deacetylaglaxiflorin A
-
Antineoplastic Agents, Phytogenic
-
Drugs, Chinese Herbal
-
Lignans