Autonomic changes following generalized tonic clonic seizures: An analysis of adult and pediatric patients with epilepsy

Rani A Sarkis; Sigride Thome-Souza; Ming-Zher Poh; Nichelle Llewellyn; Jacquelyn Klehm; Joseph R Madsen; Rosalind Picard; Page B Pennell; Barbara A Dworetzky; Tobias Loddenkemper; Claus Reinsberger

doi:10.1016/j.eplepsyres.2015.06.005

Autonomic changes following generalized tonic clonic seizures: An analysis of adult and pediatric patients with epilepsy

Epilepsy Res. 2015 Sep:115:113-8. doi: 10.1016/j.eplepsyres.2015.06.005. Epub 2015 Jun 14.

Authors

Affiliations

¹ Department of Neurology, Edward B. Bromfield Epilepsy Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: [email protected].
² Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: [email protected].
³ MIT Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: [email protected].
⁴ Department of Neurology, Edward B. Bromfield Epilepsy Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: [email protected].
⁵ Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: [email protected].
⁶ Department of Neurosurgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: [email protected].
⁷ MIT Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA; Empatica, Inc., Cambridge, MA, USA. Electronic address: [email protected].
⁸ Department of Neurology, Edward B. Bromfield Epilepsy Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: [email protected].
⁹ Department of Neurology, Edward B. Bromfield Epilepsy Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: [email protected].
¹⁰ Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: [email protected].
¹¹ Department of Neurology, Edward B. Bromfield Epilepsy Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Institute of Sports Medicine, University of Paderborn, Paderborn, Germany. Electronic address: [email protected].

PMID: 26220387
DOI: 10.1016/j.eplepsyres.2015.06.005

Abstract

Objective: Sudden unexpected death in epilepsy (SUDEP) is the most common cause of mortality directly related to epilepsy. Its incidence is higher in adult patients and its pathophysiology remains poorly understood, but likely involves autonomic dysregulation following generalized tonic clonic seizures (GTCS). In the current study, we aimed to analyze post-ictal autonomic changes following GTCS in adult and pediatric patients.

Methods: Patients admitted to the epilepsy monitoring unit were prospectively recruited, and wore an electrodermal activity (EDA) wrist sensor that continuously measured sympathetic activity while being monitored with EEG and EKG electrodes. Peri-ictal EDA parameters were assessed as a measure of sympathetic activity. Peri-ictal parasympathetic activity was determined through the high frequency component (HF) analysis of heart rate variability (HRV). The duration of post-ictal generalized EEG suppression (PGES) was also documented.

Results: Twenty patients with GTCS were included in the study on whom 30 GTCS were recorded. PGES duration strongly correlated with age (r=0.62, p=0.004) and measures of the EDA response. After controlling for PGES duration, we found pediatric patients had greater sympathetic activation measured as log rising portion of the area under the curve of the EDA response (β=+0.67, p=0.034) and a higher degree of vagal suppression measured as maximal percentage change of HF power (β=-12.65, p=0.0036).

Conclusion: Sympathetic activity can be measured in the peri-ictal period, and directly correlates with PGES duration. Age is a significant determinant of the sympathetic and parasympathetic response following a GTCS; given the same PGES duration, pediatric patients demonstrate stronger sympathetic activation and higher vagal suppression. However, the increase in PGES duration with age and the associated autonomic dysregulation may provide clues as to why there is a variable vulnerability to SUDEP across age groups.

Keywords: Autonomic nervous system; Electrodermal activity; Generalized tonic clonic seizures; Post-ictal generalized EEG suppression; Sudden unexpected death in epilepsy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aging / physiology*
Brain / physiopathology*
Child
Electrocardiography
Electroencephalography
Epilepsy, Generalized / physiopathology*
Female
Galvanic Skin Response / physiology*
Heart Rate / physiology*
Humans
Male
Middle Aged
Monitoring, Physiologic
Prospective Studies
Seizures / physiopathology*
Time Factors
Young Adult