Anthranilic acids from isatin: an efficient, versatile and environmentally friendly method

An Acad Bras Cienc. 2015 Sep;87(3):1525-9. doi: 10.1590/0001-3765201520140289. Epub 2015 Jul 28.

Abstract

This paper describes the preparation of a series of 16 anthranilic acids in yields ranging from 51 to 97%, by treating the isatins with NaOH and H2O2. Independently of the nature of the substituent on the aromatic ring, the reactions were complete in 15 min at room temperature, whereas those of isatins containing a substituent on the nitrogen atom required longer reaction time for completion (45 min) under the same reaction conditions.

Publication types

  • Research Support, Non-U.S. Gov't