Engineering Melanin Nanoparticles as an Efficient Drug-Delivery System for Imaging-Guided Chemotherapy

Adv Mater. 2015 Sep 9;27(34):5063-9. doi: 10.1002/adma.201502201. Epub 2015 Jul 29.

Abstract

In order to promote imaging-guided chemotherapy for preclinical and clinical applications, endogenous nanosystems with both contrast and drug-delivery properties are highly desired. Here, the simple use of melanin is first reported, and this biopolymer with good biocompatibility and biodegradability, binding ability to drugs and ions, and intrinsic photoacoustic properties, can serve as an efficient endogenous nanosystem for imaging-guided tumor chemotherapy in living mice.

Keywords: drug delivery; melanin nanoparticles; photoacoustic imaging; positron emission tomography (PET); sorafenib.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry*
  • Drug Carriers / chemistry*
  • Engineering*
  • Hep G2 Cells
  • Humans
  • Melanins / chemistry*
  • Mice
  • NIH 3T3 Cells
  • Nanoparticles*
  • Niacinamide / analogs & derivatives
  • Niacinamide / chemistry
  • Phenylurea Compounds / chemistry
  • Photoacoustic Techniques / methods*
  • Positron-Emission Tomography
  • Solubility
  • Sorafenib
  • Water / chemistry

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Melanins
  • Phenylurea Compounds
  • Water
  • Niacinamide
  • Sorafenib