We present the first numerical-relativity simulation of a compact-object binary whose gravitational waveform is long enough to cover the entire frequency band of advanced gravitational-wave detectors, such as LIGO, Virgo, and KAGRA, for mass ratio 7 and total mass as low as 45.5M_{⊙}. We find that effective-one-body models, either uncalibrated or calibrated against substantially shorter numerical-relativity waveforms at smaller mass ratios, reproduce our new waveform remarkably well, with a negligible loss in detection rate due to modeling error. In contrast, post-Newtonian inspiral waveforms and existing calibrated phenomenological inspiral-merger-ringdown waveforms display greater disagreement with our new simulation. The disagreement varies substantially depending on the specific post-Newtonian approximant used.