Deterministic formulas accurately forecast the decline in predictive ability of genomic prediction with changing testers, target environments or traits and truncation selection. Genomic prediction of testcross performance (TP) was found to be a promising selection tool in hybrid breeding as long as the same tester and environments are used in the training and prediction set. In practice, however, selection targets often change in terms of testers, target environments or traits leading to a reduced predictive ability. Hence, it would be desirable to estimate for given training data the expected decline in the predictive ability of genomic prediction under such settings by deterministic formulas that require only quantitative genetic parameters available from the breeding program. Here, we derived formulas for forecasting the predictive ability under different selection targets in the training and prediction set and applied these to predict the TP of lines based on line per se or testcross evaluations. On the basis of two experiments with maize, we validated our approach in four scenarios characterized by different selection targets. Forecasted and empirically observed predictive abilities obtained by cross-validation generally agreed well, with deviations between -0.06 and 0.01 only. Applying the prediction model to a different tester and/or year reduced the predictive ability by not more than 18%. Accounting additionally for truncation selection in our formulas indicated a substantial reduction in predictive ability in the prediction set, amounting, e.g., to 53% for a selected fraction α = 10%. In conclusion, our deterministic formulas enable forecasting the predictive abilities of new selection targets with sufficient precision and could be used to calculate parameters required for optimizing the allocation of resources in multi-stage genomic selection.