Development of an AIDS vaccine using Sendai virus vectors

Hiroshi Ishii; Tetsuro Matano

doi:10.1016/j.vaccine.2015.06.114

Development of an AIDS vaccine using Sendai virus vectors

Vaccine. 2015 Nov 9;33(45):6061-5. doi: 10.1016/j.vaccine.2015.06.114. Epub 2015 Jul 29.

Authors

Hiroshi Ishii¹, Tetsuro Matano²

Affiliations

¹ AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
² AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan; The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Electronic address: [email protected].

PMID: 26232346
DOI: 10.1016/j.vaccine.2015.06.114

Abstract

Development of an effective AIDS vaccine is crucial for the control of global human immunodeficiency virus type 1 (HIV-1) prevalence. We have developed a novel AIDS vaccine using a Sendai virus (SeV) vector and investigated its efficacy in a macaque AIDS model of simian immunodeficiency virus (SIV) infection. Its immunogenicity and protective efficacy have been shown, indicating that the SeV vector is a promising delivery tool for AIDS vaccines. Here, we describe the potential of SeV vector as a vaccine antigen delivery tool to induce effective immune responses against HIV-1 infection.

Keywords: AIDS vaccine; HIV; SIV; Sendai virus vector.

Publication types

Review

MeSH terms

AIDS Vaccines / administration & dosage
AIDS Vaccines / immunology*
Animals
Antibodies, Viral / blood
Antibodies, Viral / immunology
CD8-Positive T-Lymphocytes / immunology
Clinical Trials as Topic
Genetic Vectors*
HIV-1 / immunology
Humans
Macaca
Models, Animal
SAIDS Vaccines / immunology
Sendai virus / genetics*
Simian Acquired Immunodeficiency Syndrome / prevention & control
Vaccines, Synthetic

Substances

AIDS Vaccines
Antibodies, Viral
SAIDS Vaccines
Vaccines, Synthetic