Dissolvable base scaffolds allow tissue penetration of high-aspect-ratio flexible microneedles

Satoshi Yagi; Shota Yamagiwa; Yoshihiro Kubota; Hirohito Sawahata; Rika Numano; Tatsuya Imashioya; Hideo Oi; Makoto Ishida; Takeshi Kawano

doi:10.1002/adhm.201500305

Dissolvable base scaffolds allow tissue penetration of high-aspect-ratio flexible microneedles

Adv Healthc Mater. 2015 Sep 16;4(13):1949-55. doi: 10.1002/adhm.201500305. Epub 2015 Aug 2.

Authors

Affiliations

¹ Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, 441-8580, Japan.
² Department of Environmental and Life Sciences, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, 441-8580, Japan.
³ Electronics-Inspired Interdisciplinary Research Institute (EIIRIS), Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, 441-8580, Japan.

PMID: 26239876
DOI: 10.1002/adhm.201500305

Abstract

Microscale needle technology is important in electrophysiological studies, drug/chemical delivery systems, optogenetic applications, and so on. In this study, dissolvable needle-base scaffold realizes penetration of high-aspect-ratio flexible microneedles (e.g., <5 μm diameter and >500 μm length) into biological tissues. This methodology, which is applicable to numerous high-aspect-ratio flexible microneedles, should reduce the invasiveness and provide safer tissue penetrations than conventional approaches.

Keywords: brain; microneedles; penetration; silicon; silk.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cerebral Cortex / metabolism
Cerebral Cortex / pathology
Mice
Micro-Electrical-Mechanical Systems
Microscopy, Fluorescence
Needles*
Polyethylene Glycols / chemistry
Silicon / chemistry
Silk / chemistry

Substances

Silk
Polyethylene Glycols
Silicon