In Vitro Activities of Eight Antifungal Drugs against a Global Collection of Genotyped Exserohilum Isolates

Antimicrob Agents Chemother. 2015 Oct;59(10):6642-5. doi: 10.1128/AAC.01218-15. Epub 2015 Aug 3.

Abstract

The in vitro susceptibilities of 24 worldwide Exserohilum isolates belonging to 10 species from human and environmental sources were determined for eight antifungal drugs. The strains were characterized by internal transcribed spacer (ITS) sequencing and amplified fragment length polymorphism fingerprinting. Posaconazole had the lowest geometric mean MIC (0.16 μg/ml), followed by micafungin (0.21 μg/ml), amphotericin B (0.24 μg/ml), itraconazole (0.33 μg/ml), voriconazole (0.8 μg/ml), caspofungin (1.05 μg/ml), isavuconazole (1.38 μg/ml), and fluconazole (15.6 μg/ml).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / pharmacology
  • Amplified Fragment Length Polymorphism Analysis
  • Antifungal Agents
  • Ascomycota / drug effects*
  • Caspofungin
  • Echinocandins / pharmacology
  • Fluconazole / pharmacology
  • Genotype
  • Itraconazole / pharmacology
  • Lipopeptides / pharmacology
  • Micafungin
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Nitriles / pharmacology
  • Pyridines / pharmacology
  • Triazoles / pharmacology
  • Voriconazole / pharmacology

Substances

  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Nitriles
  • Pyridines
  • Triazoles
  • Itraconazole
  • isavuconazole
  • posaconazole
  • Amphotericin B
  • Fluconazole
  • Caspofungin
  • Voriconazole
  • Micafungin

Associated data

  • GENBANK/KT265236
  • GENBANK/KT265259