Norepinephrine and Corticotropin-Releasing Hormone: Partners in the Neural Circuits that Underpin Stress and Anxiety

Yajie Sun; Sarah Hunt; Pankaj Sah

doi:10.1016/j.neuron.2015.07.022

Norepinephrine and Corticotropin-Releasing Hormone: Partners in the Neural Circuits that Underpin Stress and Anxiety

Neuron. 2015 Aug 5;87(3):468-70. doi: 10.1016/j.neuron.2015.07.022.

Authors

Yajie Sun¹, Sarah Hunt¹, Pankaj Sah²

Affiliations

¹ Queensland Brain Institute, University of Queensland, St. Lucia, QLD 4072, Australia.
² Queensland Brain Institute, University of Queensland, St. Lucia, QLD 4072, Australia. Electronic address: [email protected].

PMID: 26247856
DOI: 10.1016/j.neuron.2015.07.022

Abstract

Norepinephrine and corticotropin-releasing hormone (CRH) have long been implicated in the response to stress. In this issue of Neuron, McCall et al. (2015) show that CRH projections from the central amygdala drive tonic locus coeruleus activity that evokes acute anxiety responses and place aversion.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adrenergic Neurons / metabolism*
Animals
Anxiety / metabolism*
Corticotropin-Releasing Hormone / metabolism*
Locus Coeruleus / metabolism*
Male
Stress, Psychological / metabolism*

Substances

Corticotropin-Releasing Hormone

Grants and funding

Medical Research Council/United Kingdom