Persistent rotavirus diarrhea post-transplant in a novel JAK3-SCID patient after vaccination

Pediatr Allergy Immunol. 2016 Feb;27(1):93-6. doi: 10.1111/pai.12455. Epub 2015 Oct 1.

Authors

Delfien Bogaert^{1

2}, Kristof Van Schil³, Tom Taghon⁴, Victoria Bordon⁵, Carolien Bonroy⁶, Melissa Dullaers¹, Elfride De Baere³, Filomeen Haerynck⁷

Affiliations

¹ Clinical Immunology Research Lab, Department of Pulmonary Medicine, Ghent University Hospital, Ghent, Belgium.
² Department of Pediatric Immunology and Pulmonology, Ghent University Hospital, Ghent, Belgium.
³ Center for Medical Genetics, Ghent University, Ghent University Hospital, Ghent, Belgium.
⁴ Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium.
⁵ Department of Pediatric Hematology and Oncology, Ghent University Hospital, Ghent, Belgium.
⁶ Department of Clinical Chemistry, Microbiology and Immunology, Laboratory of Clinical Biology, Ghent University Hospital, Ghent, Belgium.
⁷ Department of Pediatric Immunology and Pulmonology, Ghent University Hospital, Ghent, Belgium. [email protected].

PMID: 26248889
DOI: 10.1111/pai.12455

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Anti-Bacterial Agents / administration & dosage
Child, Preschool
DNA Mutational Analysis
Diarrhea, Infantile / diagnosis
Diarrhea, Infantile / immunology*
Diarrhea, Infantile / prevention & control
Diarrhea, Infantile / virology
Genetic Predisposition to Disease
Hematopoietic Stem Cell Transplantation*
Homozygote
Humans
Immunocompromised Host*
Immunoglobulins / administration & dosage
Infant
Janus Kinase 3 / genetics*
Male
Mutation*
Pedigree
Phenotype
Rotavirus / immunology*
Rotavirus Infections / diagnosis
Rotavirus Infections / immunology*
Rotavirus Infections / prevention & control
Rotavirus Infections / virology
Rotavirus Vaccines / adverse effects
Rotavirus Vaccines / immunology
Vaccines, Attenuated / adverse effects
Vaccines, Attenuated / immunology
X-Linked Combined Immunodeficiency Diseases / diagnosis
X-Linked Combined Immunodeficiency Diseases / enzymology
X-Linked Combined Immunodeficiency Diseases / genetics
X-Linked Combined Immunodeficiency Diseases / immunology
X-Linked Combined Immunodeficiency Diseases / surgery*

Substances

Anti-Bacterial Agents
Immunoglobulins
Rotavirus Vaccines
Vaccines, Attenuated
JAK3 protein, human
Janus Kinase 3