Comparative study of the radiobiological effects induced on adherent vs suspended cells by BNCT, neutrons and gamma rays treatments

Appl Radiat Isot. 2015 Dec:106:226-32. doi: 10.1016/j.apradiso.2015.07.054. Epub 2015 Jul 30.

Abstract

The present work is part of a preclinical in vitro study to assess the efficacy of BNCT applied to liver or lung coloncarcinoma metastases and to limb osteosarcoma. Adherent growing cell lines can be irradiated as adherent to the culture flasks or as cell suspensions, differences in radio-sensitivity of the two modalities of radiation exposure have been investigated. Dose related cell survival and cell cycle perturbation results evidenced that the radiosensitivity of adherent cells is higher than that of the suspended ones.

Keywords: BNCT; Cell cycle; Cell survival; Radiobiological effects.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Boron Neutron Capture Therapy*
  • Cell Adhesion / radiation effects*
  • Cell Cycle / radiation effects
  • Cell Line, Tumor
  • Gamma Rays*
  • Neoplasms / pathology
  • Neoplasms / radiotherapy*
  • Neutrons*
  • Rats