How phosphoubiquitin activates Parkin

Cell Res. 2015 Oct;25(10):1087-8. doi: 10.1038/cr.2015.97. Epub 2015 Aug 11.

Abstract

A recent report, solving the structure of a Parkin-phosphoubiquitin complex, greatly advances the understanding of the Parkin activation mechanism.

MeSH terms

  • Enzyme Activation
  • Humans
  • Models, Molecular
  • Phosphorylation
  • Protein Structure, Tertiary
  • Ubiquitin / chemistry
  • Ubiquitin / metabolism*
  • Ubiquitin-Protein Ligases / chemistry
  • Ubiquitin-Protein Ligases / metabolism*

Substances

  • Ubiquitin
  • Ubiquitin-Protein Ligases
  • parkin protein