Deleterious effects of skin freezing contribute to variable outcomes of the predictive drug permeation studies using hydrophilic molecules

Exp Dermatol. 2015 Dec;24(12):972-4. doi: 10.1111/exd.12825. Epub 2015 Oct 6.

Authors

Rawad Abdayem¹, Laurène Roussel¹, Nicolas Zaman¹, Fabrice Pirot¹, Elodie Gilbert¹, Marek Haftek¹

Affiliation

¹ EA4169 "Fundamental, clinical and therapeutic aspects of the skin barrier function", University of Lyon 1, Lyon, France.

PMID: 26268618
DOI: 10.1111/exd.12825

No abstract available

Keywords: ex vivo permeation tests; skin permeability barrier; stratum corneum; ultrastructure.

Publication types

Letter

MeSH terms

Animals
Epidermis / metabolism
Epidermis / ultrastructure
Extracellular Space / metabolism
Freezing*
Hydrophobic and Hydrophilic Interactions
In Vitro Techniques
Permeability
Skin / metabolism*
Skin / ultrastructure
Skin Absorption / physiology*
Swine