Falls and fractures 2 years after acute stroke: the North Dublin Population Stroke Study

Age Ageing. 2015 Sep;44(5):882-6. doi: 10.1093/ageing/afv093. Epub 2015 Aug 12.

Abstract

Background: Stroke patients are at increased risk of falls and fractures. The aim of this study was to determine the rate, predictors and consequences of falls within 2 years after stroke in a prospective population-based study in North Dublin, Ireland.

Design: Prospective population-based cohort study.

Subjects: 567 adults aged >18 years from the North Dublin Population Stroke Study.

Methods: Participants were enrolled from an Irish urban population of 294,592 individuals, according to recommended criteria. Patients were followed for 2 years. Outcome measures included death, modified Rankin Scale (mRS), fall and fracture rate.

Results: At 2 years, 23.5% (124/522) had fallen at least once since their stroke, 14.2% (74/522) had 2 or more falls and 5.4% (28/522) had a fracture. Of 332 survivors at 2 years, 107 (32.2%) had fallen, of whom 60.7% (65/107) had 2 or more falls and 23.4% (25/107) had fractured. In a multivariable model controlling for age and gender, independent risk factors for falling within the first 2 years of stroke included use of alpha-blocker medications for treatment of hypertension (P = 0.02). When mobility measured at Day 90 was included in the model, patients who were mobility impaired (mRS 2-3) were at the highest risk of falling within 2 years of stroke [odds ratio (OR) 2.30, P = 0.003] and those functionally dependent (mRS 4-5) displayed intermediate risk (OR 2.02, P = 0.03) when compared with independently mobile patients.

Conclusion: Greater attention to falls risk, fall prevention strategies and bone health in the stroke population are required.

Keywords: falls; older people; outcome; stroke.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Accidental Falls / mortality
  • Accidental Falls / statistics & numerical data*
  • Adrenergic alpha-Antagonists / therapeutic use
  • Aged
  • Aged, 80 and over
  • Antihypertensive Agents / therapeutic use
  • Chi-Square Distribution
  • Comorbidity
  • Disability Evaluation
  • Female
  • Fractures, Bone / diagnosis
  • Fractures, Bone / epidemiology*
  • Fractures, Bone / mortality
  • Humans
  • Hypertension / drug therapy
  • Hypertension / epidemiology
  • Ireland / epidemiology
  • Kaplan-Meier Estimate
  • Logistic Models
  • Male
  • Middle Aged
  • Mobility Limitation
  • Multivariate Analysis
  • Odds Ratio
  • Prevalence
  • Prognosis
  • Prospective Studies
  • Risk Factors
  • Stroke / diagnosis
  • Stroke / epidemiology*
  • Stroke / mortality
  • Time Factors
  • Urban Health

Substances

  • Adrenergic alpha-Antagonists
  • Antihypertensive Agents