Installing multifunctionality on titanium with RGD-decorated polyurethane-polyurea roxithromycin loaded nanoparticles: toward new osseointegrative therapies

Pau Rocas; Mireia Hoyos-Nogués; Josep Rocas; José M Manero; Javier Gil; Fernando Albericio; Carlos Mas-Moruno

doi:10.1002/adhm.201500245

Installing multifunctionality on titanium with RGD-decorated polyurethane-polyurea roxithromycin loaded nanoparticles: toward new osseointegrative therapies

Adv Healthc Mater. 2015 Sep 16;4(13):1956-60. doi: 10.1002/adhm.201500245. Epub 2015 Aug 14.

Authors

Pau Rocas¹, Mireia Hoyos-Nogués^{2

3}, Josep Rocas⁴, José M Manero^{2

3}, Javier Gil^{2

3}, Fernando Albericio^{1

3

5

6

7}, Carlos Mas-Moruno^{2

3}

Affiliations

¹ Institute for Research in Biomedicine (IRB Barcelona), 08028, Barcelona, Spain.
² Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering and Centre for Research in NanoEngineering (CRNE), Technical University of Catalonia (UPC), 08028, Barcelona, Spain.
³ Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 08028, Barcelona, Spain.
⁴ Nanobiotechnological Polymers Division, Ecopol Tech S.L., 43720, L'Arboç, Tarragona, Spain.
⁵ Department of Organic Chemistry, University of Barcelona, 08028, Barcelona, Spain.
⁶ School of Chemistry & Physics, University of Kwazulu-Natal, Durban, 4001, South Africa.
⁷ School of Chemistry, Yachay Tech, Yachay City of Knowledge, 100119, Urcuquí, Ecuador.

PMID: 26274361
DOI: 10.1002/adhm.201500245

Abstract

A novel class of polyurethane-polyurea nanoparticles (PUUa NPs) to install multifunctionality on biomaterials is presented. Biofunctionalization of titanium with roxithromycin loaded RGD-decorated PUUa NPs results in an outstanding improvement of osteoblast adhesion and strong suppression of bacterial attachment. This strategy represents a powerful approach to enhance the osseointegration of implant materials.

Keywords: RGD peptides; antibacterial properties; multifunctional nanomaterials; surface functionalization; titanium osseointegration.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology
Cell Line
Drug Carriers / chemistry*
Humans
Microscopy, Fluorescence
Nanoparticles / chemistry*
Oligopeptides / chemistry*
Osseointegration / drug effects
Polymers / chemistry
Polyurethanes / chemistry
Roxithromycin / chemistry*
Roxithromycin / pharmacology
Streptococcus sanguis / drug effects
Titanium / chemistry

Substances

Anti-Bacterial Agents
Drug Carriers
Oligopeptides
Polymers
Polyurethanes
Roxithromycin
polyurea
arginyl-glycyl-aspartic acid
Titanium