Malaria-Induced B Cell Genomic Instability

Gerson Rothschild; A Nikolai von Krusenstiern; Uttiya Basu

doi:10.1016/j.cell.2015.07.051

Malaria-Induced B Cell Genomic Instability

Cell. 2015 Aug 13;162(4):697-8. doi: 10.1016/j.cell.2015.07.051.

Authors

Gerson Rothschild¹, A Nikolai von Krusenstiern¹, Uttiya Basu²

Affiliations

¹ Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, NY 10032, USA.
² Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, NY 10032, USA. Electronic address: [email protected].

PMID: 26276622
DOI: 10.1016/j.cell.2015.07.051

Abstract

Nussenzweig and colleagues evaluate genomic instability and germinal center derived lymphomagenesis in mice infected with Plasmodium to recreate some of the hallmark characteristics of Burkitt lymphoma, a form of cancer more common in parts of Africa where malaria is endemic.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Cytidine Deaminase / metabolism*
Humans
Lymphoma, B-Cell / enzymology*
Lymphoma, B-Cell / genetics*
Translocation, Genetic*

Substances

Cytidine Deaminase

Abstract

Publication types

MeSH terms

Substances

Grants and funding