One-Pot Selective Homodimerization/Hydrogenation Strategy for Sequential Dicarba Bridge Formation

J Org Chem. 2015 Sep 18;80(18):9057-63. doi: 10.1021/acs.joc.5b01312. Epub 2015 Sep 9.

Abstract

The installation of interlocked dicarba bridges into peptide sequences requires the development of a regioselective and chemoselective methodology. This manuscript describes a one-pot, chemoselective synthesis of three 2,7-diaminosuberic acid derivatives from an alkyne, a cobalt-carbonyl protected alkyne, and an alkene using metathesis and homogeneous hydrogenation catalysis.

Publication types

  • Research Support, Non-U.S. Gov't