Increased vitamin D levels at birth and in early infancy increase offspring allergy risk-evidence for involvement of epigenetic mechanisms

Kristin M Junge; Tobias Bauer; Stefanie Geissler; Frank Hirche; Loreen Thürmann; Mario Bauer; Saskia Trump; Matthias Bieg; Dieter Weichenhan; Lei Gu; Jan-Philipp Mallm; Naveed Ishaque; Oliver Mücke; Stefan Röder; Gunda Herberth; Ulrike Diez; Michael Borte; Karsten Rippe; Christoph Plass; Carl Hermann; Gabriele I Stangl; Roland Eils; Irina Lehmann

doi:10.1016/j.jaci.2015.06.040

Increased vitamin D levels at birth and in early infancy increase offspring allergy risk-evidence for involvement of epigenetic mechanisms

J Allergy Clin Immunol. 2016 Feb;137(2):610-3. doi: 10.1016/j.jaci.2015.06.040. Epub 2015 Aug 15.

Authors

Kristin M Junge¹, Tobias Bauer², Stefanie Geissler³, Frank Hirche⁴, Loreen Thürmann¹, Mario Bauer¹, Saskia Trump¹, Matthias Bieg⁵, Dieter Weichenhan⁶, Lei Gu², Jan-Philipp Mallm⁷, Naveed Ishaque⁵, Oliver Mücke⁶, Stefan Röder⁸, Gunda Herberth¹, Ulrike Diez⁹, Michael Borte⁹, Karsten Rippe⁷, Christoph Plass⁶, Carl Hermann¹⁰, Gabriele I Stangl³, Roland Eils¹¹, Irina Lehmann¹²

Affiliations

¹ Department of Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
² Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
³ Institute for Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle, Germany.
⁴ Heidelberg Center for Personalized Oncology, DKFZ-HIPO, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁵ Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany; Heidelberg Center for Personalized Oncology, DKFZ-HIPO, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁶ Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁷ Research Group Genome Organization & Function, German Cancer Research Center (DKFZ) and Bioquant, Heidelberg, Germany.
⁸ Core Facility Studies, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
⁹ Children's Hospital, Municipal Hospital "St Georg", Leipzig, Germany.
¹⁰ Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute of Pharmacy and Molecular Biotechnology, and Bioquant Center, University of Heidelberg, Heidelberg, Germany.
¹¹ Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany; Heidelberg Center for Personalized Oncology, DKFZ-HIPO, German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute of Pharmacy and Molecular Biotechnology, and Bioquant Center, University of Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg, German Center for Lung Research (DZL), University of Heidelberg, Heidelberg, Germany.
¹² Department of Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany; Core Facility Studies, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany. Electronic address: [email protected].

PMID: 26282283
DOI: 10.1016/j.jaci.2015.06.040

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

DNA Methylation
Disease Susceptibility
Epigenesis, Genetic*
Genome-Wide Association Study
Humans
Hypersensitivity / epidemiology
Hypersensitivity / etiology*
Infant
Infant, Newborn
Odds Ratio
Risk
Vitamin D / blood*

Substances

Vitamin D