Cancer: leaping the E-cadherin hurdle

EMBO J. 2015 Sep 14;34(18):2307-9. doi: 10.15252/embj.201592757. Epub 2015 Aug 17.

Abstract

Aberrant activation of the Wnt signaling pathway is a common cause of colon cancer and other tumor types, accomplishing many of the hallmarks of cancer including sustained proliferative signaling, replicative immortality, reprogrammed metabolism, angiogenesis, and invasion. Yet, the dominant mutation that leads to chronic Wnt signaling in colon cancer is quite different from the spectrum of mutations that activate Wnt signaling in other tumor types. In this issue of The EMBO Journal, Huels et al (2015) focus on the influential role E-cadherin plays in shaping these differences.

Publication types

  • News
  • Comment

MeSH terms

  • Animals
  • Cadherins / metabolism*
  • Cell Transformation, Neoplastic*
  • Colonic Neoplasms*
  • Mutation*
  • Neoplasm Proteins*
  • Wnt Signaling Pathway*
  • beta Catenin*

Substances

  • Cadherins
  • Neoplasm Proteins
  • beta Catenin