Identifying patients infected with hepatitis B virus in sub-Saharan Africa: potential for misclassification

Anders Boyd; Sarah Maylin; Raoul Moh; Delphine Gabillard; Hervé Menan; Nadia Mahjoub; Christine Danel; Xavier Anglaret; Serge Paul Eholié; Pierre-Marie Girard; Fabien Zoulim; Constance Delaugerre; Karine Lacombe; ANRS 12240 VarBVA study

doi:10.1016/j.diagmicrobio.2015.07.009

Identifying patients infected with hepatitis B virus in sub-Saharan Africa: potential for misclassification

Diagn Microbiol Infect Dis. 2015 Nov;83(3):248-51. doi: 10.1016/j.diagmicrobio.2015.07.009. Epub 2015 Jul 18.

Authors

Affiliations

¹ INSERM, UMR_S1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France. Electronic address: [email protected].
² Laboratoire de Virologie, Hôpital Saint-Louis, AP-HP, Paris, France; Université Paris-Diderot, Paris, France.
³ Programme PAC-CI, ANRS Research Site, Treichville University Hospital, Abidjan, Côte d'Ivoire.
⁴ INSERM, U897, Epidémiologie-Biostatistique, Bordeaux, France; University of Bordeaux, ISPED, Bordeaux, France.
⁵ Programme PAC-CI, ANRS Research Site, Treichville University Hospital, Abidjan, Côte d'Ivoire; Centre de Diagnostic et de Recherche sur le SIDA et les Maladies Opportunistes (CeDReS), Centre Hospitalier Universitaires (CHU) de Treichville, Abidjan, Côte d'Ivoire.
⁶ Programme PAC-CI, ANRS Research Site, Treichville University Hospital, Abidjan, Côte d'Ivoire; INSERM, U897, Epidémiologie-Biostatistique, Bordeaux, France; University of Bordeaux, ISPED, Bordeaux, France.
⁷ Programme PAC-CI, ANRS Research Site, Treichville University Hospital, Abidjan, Côte d'Ivoire; Department of Infectious and Tropical Diseases, Treichville University Teaching Hospital, Abidjan, Côte d'Ivoire; Medical School, University Felix Houphouet Boigny, Abidjan, Côte d'Ivoire.
⁸ Department of Infectious and Tropical Diseases, Saint-Antoine Hospital, AP-HP, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.
⁹ Centre de Recherche sur le Cancer de Lyon, Equipes 15 et 16, INSERM, Unité 1052, CNRS, UMR 5286, Lyon, France.
¹⁰ Laboratoire de Virologie, Hôpital Saint-Louis, AP-HP, Paris, France; INSERM U941, Paris, France; Université Paris-Diderot, Paris, France.

PMID: 26283522
DOI: 10.1016/j.diagmicrobio.2015.07.009

Abstract

Most research in sub-Saharan Africa establishes hepatitis B infection via one-time hepatitis B surface antigen (HBsAg) testing. Of 237 HIV-infected patients from two clinical trials testing HBsAg positive (MiniVidas®), 206 (86.9%) had validated serological tests using another assay (Architect). Discrepancies could be due to inactive infection, highlighting the importance of assessing hepatitis B virus infection phase.

Keywords: Bias; Hepatitis B virus; Hepatitis surface antigen; Inactive hepatitis B infection; Isolated hepatitis B core antigen.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Africa South of the Sahara
Cohort Studies
DNA, Viral / blood
Female
HIV Infections / complications
Hepatitis B / diagnosis*
Hepatitis B Antibodies / blood
Hepatitis B Surface Antigens / blood*
Hepatitis B e Antigens / blood
Hepatitis B virus / isolation & purification*
Humans
Male
Middle Aged
Young Adult

Substances

DNA, Viral
Hepatitis B Antibodies
Hepatitis B Surface Antigens
Hepatitis B e Antigens