Multimodal Nanoparticle for Primary Tumor Delineation and Lymphatic Metastasis Mapping in a Head-and-Neck Cancer Rabbit Model

Nidal Muhanna; Thomas D MacDonald; Harley Chan; Cheng S Jin; Laura Burgess; Liyang Cui; Juan Chen; Jonathan C Irish; Gang Zheng

doi:10.1002/adhm.201500363

Multimodal Nanoparticle for Primary Tumor Delineation and Lymphatic Metastasis Mapping in a Head-and-Neck Cancer Rabbit Model

Adv Healthc Mater. 2015 Oct;4(14):2164-2169. doi: 10.1002/adhm.201500363. Epub 2015 Aug 18.

Authors

Nidal Muhanna^{1

2}, Thomas D MacDonald^{1

3}, Harley Chan^{1

2}, Cheng S Jin^{1

3

4}, Laura Burgess^{1

5}, Liyang Cui^{1

5

6}, Juan Chen¹, Jonathan C Irish^{1

2}, Gang Zheng^{1

3

4

5}

Affiliations

¹ Princess Margaret Cancer Centre and Techna Institute, UHN, TMDT 5-362, 101 College Street, Toronto, Ontario, M5G 1L7, Canada.
² Department of Otolaryngology-Head and Neck Surgery/Surgical Oncology, University of Toronto, 190 Elizabeth Street, Toronto, Ontario, M5G 2C4, Canada.
³ Department of Pharmaceutical Sciences, University of Toronto, Toronto, M5G 1L7, Canada.
⁴ Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, M5G 1L7, Canada.
⁵ Department of Medical Biophysics, University of Toronto, Toronto, M5G 1L7, Canada.
⁶ Medical Isotopes Research Center, Peking University, Beijing, 100191, China.

PMID: 26283596
DOI: 10.1002/adhm.201500363

Abstract

⁶⁴ Cu-porphysome nanoparticles enable superior delineation of neoplastic tissues, metastatic lymph nodes, and vascular drainage on head and neck cancer orthotopic rabbit model using positron emission tomography imaging. Additionally, the nanoparticles exhibit selective fluorescence activation in tumor and metastatic lymph nodes, which permits intraoperative real-time visualization of disease tissues to precisely define surgical margins and prevents collateral damage during surgeries.

Keywords: PET imaging; fluorescence imaging; head and neck cancer; lymph node metastases; porphysome.