Abstract
The first total chemical synthesis of the site-selective azide-labeled [I66A]HIV-1 protease is described by native chemical ligation. Chemical synthesis of azide-labeled proteins would provide useful protein tools for biochemical, biophysical or medical studies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Azides / chemical synthesis
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Azides / chemistry*
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HIV Protease / chemistry*
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Molecular Sequence Data
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Spectrometry, Mass, Electrospray Ionization
Substances
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Azides
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HIV Protease
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p16 protease, Human immunodeficiency virus 1