Immediate hypersensitivity to latex is now well known. Contact urticaria is the most common manifestation, sometimes associated with rhinitis, asthma or a generalized rash. Atopy and frequent contact with latex favor sensitization. Anaphylactic shock is to be feared in sensitized patients during contact with latex, especially in peroperative situations (latex surgical gloves), as in the 12 cases reported. The shock is unusual in its delayed appearance and its progressive course. Positive skin tests to latex, the presence of specific IgE antibodies and negative skin tests to anesthetics confirm the diagnosis. However, the latex allergen has not yet been identified. Due to the increasing use of protective rubber (gloves, condoms, etc), the frequency of latex sensitization should increase. Systematic screening during history taking will be important before treatment.