Noncoding RNAs and the control of signalling via nuclear receptor regulation in health and disease

Best Pract Res Clin Endocrinol Metab. 2015 Aug;29(4):529-43. doi: 10.1016/j.beem.2015.07.003. Epub 2015 Jul 14.

Abstract

Nuclear receptors belong to a superfamily of proteins that play central roles in human biology, orchestrating a large variety of biological functions in both health and disease. Understanding the interactions and regulatory pathways of NRs will allow development of potential therapeutic interventions for a multitude of disease processes. Non-coding RNAs have recently been discovered to have significant interactions with NR signalling pathways via a variety of biological connections. This review summarises the known interactions between ncRNAs and the NR superfamily in health, embryogenesis and a plethora of human diseases.

Keywords: Alzheimer's disease; atherosclerosis; breast cancer; gestational diabetes; lncRNA; metabolism; miRNA; neural stem cell; nuclear receptor; prostate cancer.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents, Hormonal / pharmacology
  • Antineoplastic Agents, Hormonal / therapeutic use
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / genetics
  • Breast Neoplasms / metabolism*
  • Drug Resistance, Neoplasm
  • Female
  • Humans
  • Male
  • Prostatic Neoplasms / drug therapy
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / metabolism*
  • RNA, Long Noncoding / genetics*
  • RNA, Long Noncoding / metabolism
  • Receptors, Cytoplasmic and Nuclear / antagonists & inhibitors
  • Receptors, Cytoplasmic and Nuclear / genetics*
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Signal Transduction*

Substances

  • Antineoplastic Agents, Hormonal
  • RNA, Long Noncoding
  • Receptors, Cytoplasmic and Nuclear