Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [(45)Ti](salan)Ti(dipic)

J Med Chem. 2015 Sep 24;58(18):7591-5. doi: 10.1021/acs.jmedchem.5b01167. Epub 2015 Sep 3.

Abstract

We present a novel solid-phase based (45)Ti radiolabeling methodology and the implementation of (45)Ti-PET in titanium-based antineoplastics using the showcase compound [(45)Ti](salan)Ti(dipic). This development is intended to allow elucidation of the biodistribution and pharmacokinetics of promising new Ti-based therapeutics.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacokinetics
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / chemistry*
  • Coordination Complexes / pharmacokinetics
  • HT29 Cells
  • Humans
  • Mice, Nude
  • Positron-Emission Tomography
  • Radiopharmaceuticals / chemical synthesis
  • Radiopharmaceuticals / chemistry*
  • Radiopharmaceuticals / pharmacokinetics
  • Solid-Phase Synthesis Techniques
  • Tissue Distribution
  • Titanium*
  • Xenograft Model Antitumor Assays

Substances

  • Antineoplastic Agents
  • Coordination Complexes
  • Radiopharmaceuticals
  • Titanium