Synthesis of Hindered α-Amino Carbonyls: Copper-Catalyzed Radical Addition with Nitroso Compounds

J Am Chem Soc. 2015 Sep 16;137(36):11614-7. doi: 10.1021/jacs.5b07860. Epub 2015 Sep 2.

Abstract

The synthesis of sterically hindered anilines has been a significant challenge in organic chemistry. Here we report a Cu-catalyzed radical addition with in situ-generated nitroso compounds to prepare sterically hindered amines directly from readily available materials. The transformation is conducted at room temperature, uses abundant copper salts, and is tolerant of a range of functional groups.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Copper / chemistry*
  • Ketones / chemistry*
  • Nitroso Compounds / chemistry*

Substances

  • Ketones
  • Nitroso Compounds
  • Copper