Aneuploidy: Tolerating Tolerance

Gareth A Cromie; Aimée M Dudley

doi:10.1016/j.cub.2015.06.056

Aneuploidy: Tolerating Tolerance

Curr Biol. 2015 Aug 31;25(17):R771-3. doi: 10.1016/j.cub.2015.06.056.

Authors

Gareth A Cromie¹, Aimée M Dudley²

Affiliations

¹ Pacific Northwest Diabetes Research Institute, Seattle, WA 98122, USA.
² Pacific Northwest Diabetes Research Institute, Seattle, WA 98122, USA. Electronic address: [email protected].

PMID: 26325142
DOI: 10.1016/j.cub.2015.06.056

Abstract

Individuals, and cells, vary in their ability to tolerate aneuploidy, an unbalanced chromosome complement. Tolerance mechanisms can be karyotype-specific or general. General tolerance mechanisms may allow cells to benefit from the phenotypic plasticity conferred by access to multiple aneuploid states.

Publication types

Comment

MeSH terms

Aneuploidy*
Dosage Compensation, Genetic*
Gene Dosage*
Genes, Fungal*
Models, Genetic*
Saccharomyces cerevisiae / genetics*