Overview of KRAS-Driven Genetically Engineered Mouse Models of Non-Small Cell Lung Cancer

Curr Protoc Pharmacol. 2015 Sep 1:70:14.35.1-14.35.16. doi: 10.1002/0471141755.ph1435s70.

Abstract

KRAS, the most frequently mutated oncogene in non-small cell lung cancer, has been utilized extensively to model human lung adenocarcinomas. The results from such studies have enhanced considerably an understanding of the relationship between KRAS and the development of lung cancer. Detailed in this overview are the features of various KRAS-driven genetically engineered mouse models (GEMMs) of non-small cell lung cancer, their utilization, and the potential of these models for the study of lung cancer biology.

Keywords: KRAS; lung cancer; mouse models; non-small cell lung cancer; p53.

Publication types

  • Review

MeSH terms

  • Animals
  • Carcinoma, Non-Small-Cell Lung / genetics*
  • Disease Models, Animal
  • Genetic Engineering / methods*
  • Humans
  • Lung Neoplasms / genetics*
  • Mice
  • Proto-Oncogene Proteins p21(ras) / genetics*
  • Transgenes / genetics

Substances

  • Hras protein, mouse
  • Proto-Oncogene Proteins p21(ras)