The combination of bronchial asthma and ischemic heart disease presents new qualitative problems related to the diagnosis and treatment, 476 patients with bronchial asthma above 48 years of age (mean age 56.9 years) were studied. In 294 of these patients (61.7%) ischemic heart disease was found as an accompanying disease. In 31 patients (6.15%) there were signs of past myocardial infarction. The ischemic heart diseases presented with typical clinical features in 33.33% of the patients only. In the remaining 66.67% the disease ran a silent course with-out pain. In the combination bronchial asthma and ischemic heart diseases the diagnostic criteria of the ECG in rest fall to 55%. Many pathogenic factors, facilitating and aggravating, change the clinical characteristic of the combined diseases. The combination leads to new therapeutic problems, since the therapeutic approaches to them are different and sometimes opposite. The active treatment of one of the disease may lead to iatrogenic deterioration of the other.