Abstract
The effect of tenofovir and amphotericin coadministration on kidney function is poorly characterized. We measured creatinine during induction therapy and at 4 weeks after diagnosis in Ugandans undergoing cryptococcal meningitis therapy and classified as not receiving antiretroviral therapy (ART), receiving nontenofovir ART or receiving tenofovir-based ART. Longitudinal creatinine changes and grade 2-4 creatinine adverse events were evaluated across groups. Creatinine concentrations were similar across ART groups. At 4 weeks after diagnosis, creatinine was 0.25 mg/dL higher than at diagnosis, but similar across groups. Adverse event incidence was also similar across ART groups. Tenofovir and amphotericin coadministration did not increase the risk of kidney dysfunction.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Amphotericin B / adverse effects
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Amphotericin B / therapeutic use*
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Anti-HIV Agents / adverse effects
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Anti-HIV Agents / therapeutic use*
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Antifungal Agents / adverse effects
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Antifungal Agents / therapeutic use*
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Creatinine / blood
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Deoxycholic Acid / adverse effects
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Deoxycholic Acid / therapeutic use*
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Drug Combinations
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Female
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Glomerular Filtration Rate / drug effects
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HIV Infections / drug therapy*
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Humans
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Kidney / drug effects*
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Male
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Meningitis, Cryptococcal / drug therapy*
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Middle Aged
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Tenofovir / adverse effects
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Tenofovir / therapeutic use*
Substances
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Anti-HIV Agents
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Antifungal Agents
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Drug Combinations
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Deoxycholic Acid
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Amphotericin B
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amphotericin B, deoxycholate drug combination
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Tenofovir
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Creatinine