Applications of comparative evolution to human disease genetics

Claire D McWhite; Benjamin J Liebeskind; Edward M Marcotte

doi:10.1016/j.gde.2015.08.004

Applications of comparative evolution to human disease genetics

Curr Opin Genet Dev. 2015 Dec:35:16-24. doi: 10.1016/j.gde.2015.08.004. Epub 2015 Sep 4.

Authors

Claire D McWhite¹, Benjamin J Liebeskind¹, Edward M Marcotte²

Affiliations

¹ Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, & Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, United States.
² Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, & Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, United States. Electronic address: [email protected].

Abstract

Direct comparison of human diseases with model phenotypes allows exploration of key areas of human biology which are often inaccessible for practical or ethical reasons. We review recent developments in comparative evolutionary approaches for finding models for genetic disease, including high-throughput generation of gene/phenotype relationship data, the linking of orthologous genes and phenotypes across species, and statistical methods for linking human diseases to model phenotypes.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Biological Evolution*
Disease Models, Animal
Genetic Predisposition to Disease / genetics*
Genotype
High-Throughput Nucleotide Sequencing
Humans
Mutation / genetics
Phenotype

Abstract

Publication types

MeSH terms

Grants and funding