Solitary endobronchial papillomas with false impression of malignant transformation: report of two cases and review of the literature

Int J Clin Exp Pathol. 2015 Jul 1;8(7):8607-12. eCollection 2015.

Abstract

Solitary endobronchial papillomas (SEPs) are rare benign tumors of the lung, seldom transform to malignancy. This tumor had been reported occasionally manifest like carcinomas histologically. Herein we report 2 cases of SEPs; one is a squamous cell papilloma providing a false impression of interstitial micro-invasion. The other is a mixed squamous cell and glandular papilloma with massive lipid pneumonia gross appearance, and focally resembles adenocarcinoma with lepidic-like pattern on histological examination. A review of associated literatures was provided.

Keywords: SEP; lung; misdiagnosis; tumor.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenocarcinoma / chemistry
  • Adenocarcinoma / pathology*
  • Adenocarcinoma / surgery
  • Adenocarcinoma of Lung
  • Aged
  • Biomarkers, Tumor / analysis
  • Biopsy
  • Cell Transformation, Neoplastic / chemistry
  • Cell Transformation, Neoplastic / pathology*
  • Diagnostic Errors*
  • Female
  • Humans
  • Immunohistochemistry
  • Lung Neoplasms / chemistry
  • Lung Neoplasms / pathology*
  • Lung Neoplasms / surgery
  • Male
  • Middle Aged
  • Papilloma / chemistry
  • Papilloma / pathology*
  • Papilloma / surgery
  • Predictive Value of Tests
  • Solitary Pulmonary Nodule / chemistry
  • Solitary Pulmonary Nodule / pathology*
  • Solitary Pulmonary Nodule / surgery
  • Tomography, X-Ray Computed

Substances

  • Biomarkers, Tumor