pUBLically unzipping Parkin: how phosphorylation exposes a ligase bit by bit

EMBO J. 2015 Oct 14;34(20):2486-8. doi: 10.15252/embj.201592857. Epub 2015 Sep 7.

Abstract

Disposal of damaged mitochondria is tightly controlled by auto-inhibition mechanisms that keep the ubiquitin ligase Parkin in check. Several new structural studies provide insight into how PINK1-dependent phosphorylation of ubiquitin and Parkin may progressively relieve Parkin auto-inhibition.

Publication types

  • Comment

MeSH terms

  • Enzyme Activation / genetics*
  • Humans
  • Mitochondria / metabolism*
  • Models, Biological*
  • Models, Molecular*
  • Protein Kinases / chemistry*
  • Protein Kinases / metabolism*
  • Ubiquitin-Protein Ligases / chemistry*
  • Ubiquitin-Protein Ligases / metabolism*

Substances

  • Ubiquitin-Protein Ligases
  • Protein Kinases