Abstract
Stereoselective synthesis of D-5-homo-4-selenoribose, serving as a versatile intermediate for the synthesis of 4'-selenonucleosides 12a-c, was accomplished using Sharpless asymmetric epoxidation, regioselective cleavage of the α,β-epoxide, and stereoselective reduction of the ketone as the key steps.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Epoxy Compounds / chemistry
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Molecular Structure
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Nucleosides / chemical synthesis*
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Nucleosides / chemistry
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Organoselenium Compounds / chemical synthesis*
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Organoselenium Compounds / chemistry
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Stereoisomerism
Substances
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D-5-homo-4-selenoribose
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Epoxy Compounds
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Nucleosides
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Organoselenium Compounds