1 Scientific Institute IRCCS Eugenio Medea, Lecco, Italy Scientific Institute IRCCS Eugenio Medea, Lecco, Italy, Unit of Clinical Pharmacology, CNR Institute of Neuroscience, Department of Biomedical and Clinical Sciences L. Sacco, "Luigi Sacco" University Hospital, Università di Milano, Milan, Italy Scientific Institute IRCCS Eugenio Medea, Lecco, Italy.