Abstract
Methods of synthesis, chemical properties and results of preliminary pharmacological screening for 8-amino substituted derivatives of caffeine (1-3) and 7,8-disubstituted derivatives of 8-aminotheophylline (8-12) have been described. The compounds show weak sedative and antidepressive activity and some of them (2, 10, 12) also small antinociceptive effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics
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Animals
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Anticonvulsants
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Apomorphine / antagonists & inhibitors
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Body Temperature / drug effects
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Chemical Phenomena
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Chemistry
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Haloperidol / antagonists & inhibitors
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Lethal Dose 50
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Male
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Mice
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Motor Activity / drug effects
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Piperazines / antagonists & inhibitors
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Psychomotor Performance / drug effects
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Rats
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Rats, Inbred Strains
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Reserpine / antagonists & inhibitors
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Xanthines / chemical synthesis
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Xanthines / pharmacology*
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Xanthines / toxicity
Substances
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Analgesics
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Anticonvulsants
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Piperazines
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Xanthines
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Reserpine
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3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid
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Haloperidol
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Apomorphine