Inside Job: Viruses Transfer cGAMP between Cells

Muhammet F Gulen; Andrea Ablasser

doi:10.1016/j.chom.2015.08.008

Inside Job: Viruses Transfer cGAMP between Cells

Cell Host Microbe. 2015 Sep 9;18(3):263-5. doi: 10.1016/j.chom.2015.08.008.

Authors

Muhammet F Gulen¹, Andrea Ablasser²

Affiliations

¹ Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
² Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address: [email protected].

PMID: 26355209
DOI: 10.1016/j.chom.2015.08.008

Abstract

The DNA sensor, cyclic GMP-AMP synthase (cGAS), is essential for the detection of viral infection. In a recent issue of Science, two studies, Bridgeman et al. (2015) and Gentili et al. (2015), report a novel mechanism for propagating an antiviral signal between cells, based on the transfer of the cGAS enzymatic product, cyclic GMP-AMP (cGAMP), in viral particles.

Publication types

Comment

MeSH terms

Animals
Dendritic Cells / immunology*
HIV Infections / immunology*
HIV-1 / metabolism*
Herpes Simplex / immunology*
Herpesviridae Infections / immunology*
Herpesvirus 1, Human / metabolism*
Humans
Immunity, Innate / immunology*
Interferon-beta / immunology*
Muromegalovirus / metabolism*
Nucleotides, Cyclic / metabolism*
Second Messenger Systems*
Vaccinia / immunology*
Vaccinia virus / metabolism*
Virion / metabolism*

Substances

Nucleotides, Cyclic
Interferon-beta