Jubanines F-J, cyclopeptide alkaloids from the roots of Ziziphus jujuba

Phytochemistry. 2015 Nov:119:90-5. doi: 10.1016/j.phytochem.2015.09.001. Epub 2015 Sep 8.

Abstract

Five Ib-type cyclopeptide alkaloids, jubanines F-J (1-5), and three known compounds, nummularine B (6), daechuine-S3 (7), and mucronine K (8) were isolated from the roots of Ziziphus jujuba. Their structures were fully characterized by spectroscopic analyses in combination with chemical derivatization. Compounds 1-3, and 6 were evaluated for their antiviral activity against the porcine epidemic diarrhea virus (PEDV). Compounds 2, 3, and 6 showed potent inhibitory effects on PEDV replication.

Keywords: Antiviral; Cyclopeptide alkaloids; Jubanines; Rhamnaceae; Ziziphus jujuba.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / isolation & purification*
  • Peptides, Cyclic / pharmacology
  • Plant Roots / chemistry
  • Porcine epidemic diarrhea virus / drug effects
  • Republic of Korea
  • Ziziphus / chemistry*

Substances

  • Alkaloids
  • Antiviral Agents
  • Peptides, Cyclic