A cluster of rapid disease progressors upon primary HIV-1 infection shared a novel variant with mutations in the p6gag/pol and pol/vif genes

AIDS. 2015 Aug 24;29(13):1717-9. doi: 10.1097/QAD.0000000000000771.

Abstract

Few studies have described the etiologic factors associated with rapid AIDS onset during primary HIV-1 infection. Our molecular epidemiological study identified a cluster of individuals infected with HIV-1 variants characterized by novel mutations in the p6 and pol/vif genes during 2011 and 2013 in Osaka, Japan. Individuals positive for the novel HIV-1 variant showed rapid disease progression, suggesting a role of viral mutations in the fostering of the clinical course of HIV-1 infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Cluster Analysis
  • HIV Infections / epidemiology
  • HIV Infections / pathology*
  • HIV Infections / virology*
  • HIV-1 / classification
  • HIV-1 / genetics*
  • HIV-1 / isolation & purification
  • Humans
  • Japan / epidemiology
  • Molecular Epidemiology
  • Molecular Sequence Data
  • Mutation, Missense*
  • gag Gene Products, Human Immunodeficiency Virus / genetics*
  • pol Gene Products, Human Immunodeficiency Virus / genetics*
  • vif Gene Products, Human Immunodeficiency Virus / genetics*

Substances

  • gag Gene Products, Human Immunodeficiency Virus
  • p6 gag protein, Human immunodeficiency virus 1
  • pol Gene Products, Human Immunodeficiency Virus
  • vif Gene Products, Human Immunodeficiency Virus