Specificity of vascular endothelial growth factor treatment for radiation necrosis

Carlos J Perez-Torres; Liya Yuan; Robert E Schmidt; Keith M Rich; Robert E Drzymala; Dennis E Hallahan; Joseph J H Ackerman; Joel R Garbow

doi:10.1016/j.radonc.2015.09.004

Specificity of vascular endothelial growth factor treatment for radiation necrosis

Radiother Oncol. 2015 Nov;117(2):382-5. doi: 10.1016/j.radonc.2015.09.004. Epub 2015 Sep 12.

Authors

Carlos J Perez-Torres¹, Liya Yuan², Robert E Schmidt³, Keith M Rich⁴, Robert E Drzymala⁴, Dennis E Hallahan⁵, Joseph J H Ackerman⁶, Joel R Garbow⁷

Affiliations

¹ Department of Radiology, Washington University, Saint Louis, United States.
² Department of Neurosurgery, Washington University, Saint Louis, United States.
³ Department of Neuropathology, Washington University, Saint Louis, United States.
⁴ Department of Neurosurgery, Washington University, Saint Louis, United States; Department of Radiation Oncology, Washington University, Saint Louis, United States.
⁵ Department of Radiation Oncology, Washington University, Saint Louis, United States; The Alvin J. Siteman Cancer Center, Washington University, Saint Louis, United States.
⁶ Department of Radiology, Washington University, Saint Louis, United States; Department of Chemistry, Washington University, Saint Louis, United States; Department of Internal Medicine, Washington University, Saint Louis, United States; The Alvin J. Siteman Cancer Center, Washington University, Saint Louis, United States.
⁷ Department of Radiology, Washington University, Saint Louis, United States; The Alvin J. Siteman Cancer Center, Washington University, Saint Louis, United States. Electronic address: [email protected].

Abstract

Recently, radiation induced necrosis in the brain has been treated using bevacizumab, an anti-VEGF antibody. We validated the VEGF specificity by comparing the therapeutic efficacy of anti-VEGF with non-specific isotype control antibody. Additionally, we found that VEGF over-expression and RN developed simultaneously, which precludes preventative anti-VEGF treatment.

Keywords: Magnetic resonance imaging; Radiation necrosis; Vascular endothelial growth factor.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / pathology*
Brain / radiation effects*
Disease Models, Animal
Female
Magnetic Resonance Imaging
Mice
Mice, Inbred BALB C
Necrosis / drug therapy
Radiation Injuries, Experimental / therapy*
Sensitivity and Specificity
Vascular Endothelial Growth Factor A / therapeutic use*

Substances

Vascular Endothelial Growth Factor A

Abstract

Publication types

MeSH terms

Substances

Grants and funding