1 Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, The Netherlands, and Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Amsterdam, The Netherlands Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, The Netherlands Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, The Netherlands.