Guillain-BarrÉ Syndrome After Immunization in Canadian Children (1996-2012)

Karina A Top; Shalini Desai; Dorothy Moore; Barbara J Law; Wendy Vaudry; Scott A Halperin; Julie A Bettinger; Canadian Immunization Monitoring Program Active

doi:10.1097/INF.0000000000000903

Guillain-BarrÉ Syndrome After Immunization in Canadian Children (1996-2012)

Pediatr Infect Dis J. 2015 Dec;34(12):1411-3. doi: 10.1097/INF.0000000000000903.

Authors

Karina A Top¹, Shalini Desai, Dorothy Moore, Barbara J Law, Wendy Vaudry, Scott A Halperin, Julie A Bettinger; Canadian Immunization Monitoring Program Active

Affiliation

¹ From the *Department of Pediatrics, Dalhousie University, IWK Health Centre, Halifax, Nova Scotia, Canada; †Centre for Immunization and Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, Ontario, Canada; ‡Division of Infectious Diseases, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada; §Department of Pediatrics, University of Alberta, Stollery Children's Hospital, Edmonton, Alberta, Canada; ¶Department of Pediatrics, University of British Columbia, BC Children's Hospital, Vancouver, British Columbia, Canada; and ‖The members of the Canadian Immunization Monitoring Program Active are provided in the Appendix.

PMID: 26379167
DOI: 10.1097/INF.0000000000000903

Abstract

Guillain-Barré syndrome (GBS) cases admitted to Canadian pediatric tertiary care centers were ascertained through active surveillance. From 1996 to 2012, 246 cases were identified, and 24 (10%) had onset ≤30 days after immunization. Annual rate of postimmunization GBS was 2.0 per 100,000 hospitalizations. Postimmunization GBS was an infrequent cause of pediatric hospitalization.

MeSH terms

Adolescent
Canada / epidemiology
Child
Child, Preschool
Female
Guillain-Barre Syndrome / epidemiology*
Guillain-Barre Syndrome / etiology*
Humans
Immunization / adverse effects*
Infant
Male
Retrospective Studies