Effect of Intercurrent Infections and Vaccinations on Immune and Inflammatory Biomarkers Among Human Immunodeficiency Virus-Infected Adults on Suppressive Antiretroviral Therapy

Darrell H S Tan; Leah Szadkowski; Janet Raboud; Tae Joon Yi; Brett Shannon; Rupert Kaul; W Conrad Liles; Sharon Walmsley

doi:10.1093/ofid/ofv036

Effect of Intercurrent Infections and Vaccinations on Immune and Inflammatory Biomarkers Among Human Immunodeficiency Virus-Infected Adults on Suppressive Antiretroviral Therapy

Open Forum Infect Dis. 2015 Mar 9;2(2):ofv036. doi: 10.1093/ofid/ofv036. eCollection 2015 Apr.

Authors

Darrell H S Tan¹, Leah Szadkowski², Janet Raboud³, Tae Joon Yi⁴, Brett Shannon⁴, Rupert Kaul⁵, W Conrad Liles⁶, Sharon Walmsley⁷

Affiliations

¹ Departments of Medicine ; Division of Infectious Diseases , St. Michael's Hospital ; Division of Infectious Diseases ; Toronto General Research Institute , University Health Network , Ontario, Canada.
² Toronto General Research Institute , University Health Network , Ontario, Canada.
³ Dalla Lana School of Public Health , University of Toronto ; Toronto General Research Institute , University Health Network , Ontario, Canada.
⁴ Immunology.
⁵ Departments of Medicine ; Immunology ; Division of Infectious Diseases ; Toronto General Research Institute , University Health Network , Ontario, Canada.
⁶ Department of Medicine , University of Washington , Seattle.
⁷ Departments of Medicine ; Division of Infectious Diseases ; Toronto General Research Institute , University Health Network , Ontario, Canada.

Abstract

We used generalized estimating equations to quantify the impact of recent vaccination or intercurrent infections on immune and inflammatory biomarkers among 144 human immunodeficiency virus (HIV)-infected adults with HIV RNA < 50 copies/mL on antiretroviral therapy. These events were associated with a 2.244 µg/mL increase in high sensitivity C-reactive protein and should be routinely assessed in future studies.

Keywords: C-reactive protein; HIV; immune activation; infections; inflammatory biomarkers; vaccinations.